High Power Output
Up to 500W continuous wave (CW) or pulsed output. Scalable configurations from 100W to multi-kilowatt systems for different clinical applications.
Therapeutic Ultrasound Technology
HIFU RF
HIFU RF
Power Generator
High-performance RF power amplifiers engineered for focused ultrasound applications. Drive piezoelectric transducers with precision and reliability for tumor ablation, neurological therapy, and aesthetic treatments—trusted by HIFU system developers worldwide.
500W
Max Power
0.5-7
MHz Range
MRI
Compatible
250
WATTS
FWD
REF
RF OUT
TRIG
Focused Ultrasound Energy
Understanding HIFU Technology
What is High-Intensity Focused Ultrasound?
High-Intensity Focused Ultrasound (HIFU) is a non-invasive therapeutic technique that uses focused acoustic energy to precisely heat and ablate tissue deep within the body—without incisions or radiation.
How HIFU works: An RF power generator drives piezoelectric transducers that convert electrical energy into ultrasound waves. These waves are focused—like sunlight through a magnifying glass—to a precise focal point in the tissue, where temperatures can reach 60-85°C, causing coagulative necrosis of the target tissue while sparing surrounding structures.
The RF generator's role is critical: it must deliver stable, precisely controlled power at the exact frequency required by the transducer, with fast response times for real-time treatment control. Power output, frequency stability, and impedance matching directly impact treatment efficacy and safety.
Market growth: The global HIFU market reached $1.2 billion in 2024, driven by increasing adoption in oncology (41% market share), neurology, and aesthetics. Non-invasive alternatives to surgery are in high demand.
HIFU System Components
-
01
RF Power Generator
Converts AC power to precise RF signal at transducer resonant frequency
-
02
Matching Network
Optimizes power transfer between generator and transducer
-
03
Piezoelectric Transducer
Converts RF energy to focused acoustic waves
-
04
Imaging & Control
Real-time guidance via ultrasound or MRI for precise targeting
Product Features
HIFU RF Generator Capabilities
Engineered for demanding therapeutic applications with the precision and reliability required for clinical and research HIFU systems.
Wide Frequency Range
0.5 MHz to 7 MHz covers all HIFU applications—from deep tissue ablation (0.5-1 MHz) to superficial aesthetic treatments (3-7 MHz).
Multi-Channel Arrays
Support for phased array transducers with up to 256 independently controlled channels. Electronic beam steering and focal point adjustment.
Fast Response Time
<10 μs rise/fall times for precise pulsed operation. Real-time power control for temperature-guided therapy and motion tracking.
Built-in Safety Systems
VSWR protection, over-temperature shutdown, and arc detection. Hardware interlocks and software limits ensure safe operation.
Digital Control Interface
USB, RS-232, and Ethernet interfaces for system integration. Full programmable control via API with LabVIEW and Python drivers.
Clinical & Research Applications
HIFU Applications
Our RF power generators support the full spectrum of focused ultrasound applications—from life-saving tumor ablation to cutting-edge research.
Oncology & Tumor Ablation
Non-invasive treatment of solid tumors in prostate, liver, breast, kidney, and bone. HIFU offers an alternative to surgery for patients who are not surgical candidates. The 2024 oncology segment represents 41% of the global HIFU market, with FDA-cleared systems like Focal One® driving adoption.
Neurology & Brain Therapy
MRI-guided focused ultrasound for essential tremor, Parkinson's disease tremor, and neuropathic pain. HIFU can create precise lesions in deep brain structures without opening the skull—a breakthrough alternative to invasive neurosurgery. Our MRI-compatible generators enable integration with MRgFUS platforms.
Aesthetic & Cosmetic
Non-invasive skin tightening, wrinkle reduction, and body contouring. Higher frequency HIFU (3-7 MHz) targets the SMAS layer and subcutaneous fat for cosmetic improvement without surgery. The aesthetic HIFU segment is the fastest-growing market, driven by consumer demand for minimally invasive treatments.
Research & Development
Flexible configurations for academic and industrial R&D. Develop new HIFU applications, validate treatment protocols, and characterize transducer performance. Our generators support the full research cycle from bench experiments to preclinical studies and regulatory submissions.
OEM System Integration
Designed for integration into commercial HIFU systems. Compact form factor, comprehensive API, and regulatory documentation support FDA 510(k) and CE marking submissions. Volume pricing and design-in support for OEM partnerships.
Drug Delivery & Sonoporation
Low-intensity pulsed HIFU for enhanced drug delivery, blood-brain barrier opening, and sonodynamic therapy research. Precise pulse control enables investigation of bioeffects beyond thermal ablation.
Technical Details
RF Generator Specifications
Available in multiple configurations to match your application requirements. Custom specifications available for OEM projects.
Frequency Range
0.5 – 7.0 MHz
Frequency Stability
±10 ppm
Output Power (CW)
100W / 250W / 500W models
Output Power (Pulsed)
Up to 1000W peak
Power Resolution
0.1W (digital control)
Rise/Fall Time
<10 μs
Duty Cycle
0-100% (CW or pulsed)
Output Impedance
50Ω nominal
VSWR Protection
Auto-shutdown at 3:1
Control Interfaces
USB, RS-232, Ethernet, Trigger
Cooling
Forced air / Water options
MRI Compatibility
Optional shielded version
500
WATTS
FWD
REF
Available: 100W, 250W, 500W Models
Why JJ&A Instruments
The HIFU Generator Advantage
Purpose-built for therapeutic ultrasound with the reliability and support that medical device developers demand.
Medical-Grade Quality
ISO 13485 certified manufacturing. Designed and documented to support FDA 510(k) and CE marking submissions for your HIFU system.
Applications Engineering
Our RF engineers understand HIFU applications. Get expert support for transducer matching, thermal management, and system integration.
Global Availability
Worldwide shipping with local support in North America, Europe, and Asia-Pacific. Evaluation units available for qualified projects.
Comprehensive APIs
Full software control via documented APIs. LabVIEW VIs, Python libraries, and C/C++ SDK included. Rapid integration with your control system.
Long-Term Support
5-year product availability guarantee. Extended warranty options. Calibration and maintenance services to keep your system running.
Custom Configurations
Need a specific frequency, power level, or form factor? Our engineering team can customize generators for your unique requirements.
Common Questions
HIFU Generator FAQ
What is HIFU and how does it work?
High-Intensity Focused Ultrasound (HIFU) uses focused acoustic energy to heat and destroy targeted tissue non-invasively. An RF power generator drives piezoelectric transducers that convert electrical energy into ultrasound waves. These waves are focused to a precise point in the body—like sunlight through a magnifying glass—where temperatures reach 60-85°C, causing thermal ablation of the target tissue while sparing surrounding structures.
What frequency should I use for my HIFU application?
Frequency selection depends on treatment depth and target tissue. Lower frequencies (0.5-1 MHz) penetrate deeper (up to 15 cm) and are used for tumor ablation in liver, kidney, and prostate. Mid-range frequencies (1-3 MHz) are common for neurological HIFU and general therapeutic applications. Higher frequencies (3-7 MHz) provide precise, shallow penetration for aesthetic treatments targeting skin layers. Our team can help you select the optimal frequency for your specific application.
Is the generator compatible with MRI environments?
Yes. We offer MRI-compatible versions with EMI shielding and non-magnetic construction for MR-guided Focused Ultrasound (MRgFUS) applications. These generators can operate inside the MRI suite without interfering with imaging. The shielded version has been validated at 1.5T and 3T field strengths. Contact us to discuss your specific MRI integration requirements.
Can the generator drive phased array transducers?
Yes. We offer multi-channel configurations with up to 256 independently controlled channels for phased array transducers. Each channel provides individual amplitude and phase control for electronic beam steering and focal point adjustment. Multi-channel systems include synchronization features for coherent operation. Single-element and annular array transducers are also fully supported.
What safety features are included?
Safety is built into every generator: VSWR protection automatically reduces power if reflected power exceeds safe limits (prevents transducer damage). Over-temperature protection monitors internal temperatures and shuts down before overheating. Arc detection instantly cuts power if arcing is detected in the RF path. Hardware interlocks support external safety switches and emergency stops. Software limits allow you to define application-specific power and duration limits.
What regulatory documentation is available?
We provide comprehensive documentation to support your regulatory submissions: Design history file including specifications, test reports, and traceability. Risk analysis per ISO 14971. EMC test reports per IEC 60601-1-2. Electrical safety testing per IEC 60601-1. Certificates of conformance and calibration. Our regulatory affairs team can assist with FDA 510(k) and CE marking questions.
Do you support OEM integration and custom configurations?
Yes. We work closely with HIFU system developers on OEM projects: Custom frequencies matched to your transducer. Modified form factors for integration into your system enclosure. Custom interfaces and control protocols. Private labeling available. Volume pricing for production quantities. We can also provide design-in support, prototypes, and engineering samples for evaluation.
What is the warranty and support policy?
Standard warranty is 2 years covering parts and labor. Extended warranty options up to 5 years are available. Support includes: Phone and email technical support during business hours. Remote diagnostics via network connection. Repair and calibration services at our facility. Loaner units available for qualified customers during repairs. On-site service available for an additional fee.
Get Started
Request a Quote
Ready to power your HIFU application? Contact us for pricing, specifications, or to discuss your project requirements with our engineering team.
Call Us
1-800-555-0123
Email
hifu@fisher-instruments.com